Edward Leonard

PROFESSOR OF CHEMICAL ENGINEERING PROFESSOR OF BIOMEDICAL ENGINEERING

812 S.W. Mudd
Mail Code 4721

Tel(212) 854-4448
Fax(212) 854-3054

Edward Leonard founded in 1968 and has since directed Columbia’s Artificial Organs Research Laboratory within Chemical Engineering.  His work is focused on transport and rate processes in biological systems, natural and artificial, especially the artificial kidney and transport among organs by blood. 

Research Interests

Artificial organs, transport and rate phenomena in biological systems, identification of the meta-scale between cells and organs. Rate processes involving blood.

Research Areas

Current projects in Leonard’s lab range from identifying and mitigating organ failure through the use of artificial organs, with a strong interest in membranes – their intrinsic behavior, interaction with flowing fluids, and their compatibility with blood. 

Professor Leonard has taught all the principal courses in the chemical engineering undergraduate program, as well as specialized courses in biochemical engineering. He was the originator of the biological transport course in the Department of Biomedical Engineering, which he helped found.  He currently teaches annually the eponymous course “Artificial Organs” with participation by Austrian collaborators.  His recent interest lies in the poorly understood  processes by which cells assemble into organs and regenerate after injury to “remodel” sick organs -- with the expectation that better emulation of these processes will lead to better, less-artificial organs.

Leonard has taught at Columbia Engineering since 1958. He holds a BS in chemical engineering from the Massachusetts Institute of Technology, 1953, and a PhD in chemical engineering from the University of Pennsylvania, 1960.   He is a consultant to industry, foundations, and government.

PROFESSIONAL AFFILIATIONS

  • American Institute of Chemical Engineers (Fellow)
  • American Society of Artificial Internal Organs (Past President)
  • American Institute of Medical and Biological Engineers (Founding Fellow)
  • European Society of Artificial Organs

 

 

 

HONORS & AWARDS

  • Colburn Award, American Institute of Chemical Engineers, (1969)

SELECTED PUBLICATIONS

  • Cacciatore, J. J., Leonard, E. F. & Chasin, L. A. The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate. JOURNAL OF BIOTECHNOLOGY 164, 346–353 (2013).
  • Dickson, M. N. et al. Efficient capture of circulating tumor cells with a novel immuno-cytochemical  microfluidic device. BIOMICROFLUIDICS 5, (2011).
  • John, M. & Leonard, E. F. A Method of Comparison of Different Regimens for Dialyzing Single-Pool Solutes. ASAIO J. 57, 433–438
  • Leonard, E. F., Cortell, S. & Jones, J. The Path to Wearable Ultrafiltration and Dialysis Devices. Blood Purif. 31, 92–95 (2011).
  • Leonard, E. F. et al. AMBULATORY ULTRAFILTRATION: DRY WEIGHT ALL THE TIME. Int. J. Artif. Organs 33, 428–428 (2010).
  • Nanne, E. E., Aucoin, C. P. & Leonard, E. F. Molecular movement of bovine albumin in flowing suspensions of bovine erythrocytes. CHEMICAL ENGINEERING SCIENCE 65, 6389–6396 (2010).
  • Dickson, M. N., Amar, L., Hill, M., Schwartz, J. & Leonard, E. F. A scalable, micropore, platelet rich plasma separation device. BIOMEDICAL MICRODEVICES 14, 1095–1102 (2012).
  •  Zhu, F. et al. Adjustment of dry weight in hemodialysis patients using intradialytic continuous multifrequency bioimpedance of the calf. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 27, 104–109 (2004).
  •  Jockusch, S., Lee, D., Turro, N. J. & Leonard, E. F. Photo-induced inactivation of viruses: Adsorption of methylene blue, thionine, and thiopyronine on Q beta bacteriophage. Proc. Natl. Acad. Sci. U. S. A. 93, 7446–7451 (1996).