Christoph Juchem

ASSOCIATE PROFESSOR OF BIOMEDICAL ENGINEERING AND RADIOLOGY (PHYSICS)

351 Engineering Terrace
Mail Code 8904

Tel(212) 305-2693
Fax(212) 854-8725

Christoph Juchem’s research focuses on the improvement of technology and methods to enhance the clinical potential of magnetic resonance imaging (MRI) and spectroscopy (MRS). The goal of his laboratory is to provide crucial tools to obtain information early in the development of multiple sclerosis and other neurological conditions with dedicated MRI/MRS techniques. 

Research Interests

Biomedical engineering, medical devices, biochemistry, neurodegeneration, neuroscience, translational/clinical research, multiple sclerosis, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), medical devices, MR sequence development, magnetic field modeling, B0/B1 shimming, dynamic multi-coil technique (DYNAMITE), biomedical technology, clinical trials.

Of particular interest to Juchem are the physical and engineering challenges that have prevented magnetic resonance technology from realizing its full clinical potential, such as limited B0 field behavior in the human brain. He developed a novel, generalized method for the synthesis of magnetic field shapes that allows unrivaled B0 magnetic field homogeneity as a prerequisite for meaningful MRI and MRS. Due to the inherently interdisciplinary design of his research program, Juchem works closely with a range of scientists and clinicians.

Juchem received a MS (Diplom) in physics from the University of Bonn in 2001 and a PhD (Dr. rer. nat.) in physics from the University of Tübingen in 2006. Juchem has more than 15 years of experience in developing and conducting magnetic resonance experiments in animal models and humans, and has authored more than 30 scientific publications, book chapters and patents. He is a Clinical and Translational Science Award (CTSA) scholar and has been a finalist of the I.I. Rabi Young Investigator Award of the International Society for Magnetic Resonance in Medicine (ISMRM). Christoph served as Chair of the ISMRM’s MR Engineering Study Group, journal reviewer for more than 15 peer-reviewed scientific journals (including Magnetic Resonance in Medicine Distinguished Reviewer in 2014/2016), and grant reviewer for 4 national research societies. In 2016, he joined Columbia from Yale University, where he successfully pursued clinical MRI/MRS research as Assistant Professor (2012-2016) and served as Co-Director of the 7 Tesla Brain MR Spectroscopy Core. At Columbia, he teaches Principles of Magnetic Resonance Imaging in the Department of Biomedical Engineering.

Research Experience

  • Associate Research Scientist, Yale University, 2008–2011
  • Postdoctoral Associate, Yale University, 2007–2008

Professional Experience

  • Associate Professor (Tenure Track) of Biomedical Engineering and Radiology, Columbia University, 2016–
  • Assistant Professor (Tenure Track) of Diagnostic Radiology and Neurology, Yale University, 2012–2016

Honors & Awards

  • Clinical and Translational Science Award (CTSA) Scholar, YCCI, New Haven, CT, 2013
  • Finalist, Rabi Young Investigator Award, ISMRM Annual Meeting, Montreal, QC, Canada, 2011
  • Stipend of the German Scholars Organization (GSO), Berlin, Germany, 2011
  • Best scientific poster in engineering, ISMRM Annual Meeting, Stockholm, Sweden, 2010
  • Brown Coxe Postdoctoral Fellowship in the Medical Sciences, Yale University, 2007

Selected Publications

  • Prinsen H, de Graaf RA, Mason GF, Pelletier D, Juchem C. Towards Pathoneurochemical Profiling of Multiple Sclerosis: Single-Session Measurement of Glutathione, GABA and Glutamate with MR Spectroscopy at 7 Tesla. J Magn Reson Imaging 45:187-198 (2017).
  • Juchem C, Nahhass OM, Nixon TW, de Graaf RA. Multi-Slice Magnetic Resonance Imaging with the Dynamic Multi-Coil Technique. NMR Biomed 28:1526-1534 (2015).
  • Juchem C*, Umesh Rudrapatna*, Nixon TW, de Graaf RA. Dynamic Multi-Coil Technique (DYNAMITE) Shimming for Echo-Planar Imaging of the Human Brain at 7 Tesla. *contributed equally. NeuroImage 105:462-472 (2015).
  • Juchem C, Herman P, Sanganahalli BG, Nixon TW, Brown PB, McIntyre S, Hyder F, de Graaf RA. Dynamic Multi-Coil Technique (DYNAMITE) Shimmed EPI of the Rat Brain at 11.7 Tesla. NMR Biomed 27, 897-906 (2014).
  • Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL, de Graaf RA. Dynamic Multi-Coil Shimming of the Human Brain at 7 Tesla. J Magn Reson 212, 280-288 (2011).
  • Juchem C, Brown PB, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Multi-Coil Shimming of the Mouse Brain. Magn Reson Med 66, 893-900 (2011).
  • Juchem C, Nixon TW, McIntyre S, Rothman DL, de Graaf RA. Magnetic Field Modeling with a Set of Individual Localized Coils. J Magn Reson 204, 281-289 (2010).
  • Juchem C. Passive Shimming for MR Spectroscopy at High Magnetic Fields. US Patent 7,459,908 B2 (2008)
  • Juchem C, Logothetis NK, Pfeuffer J. 1H MR Spectroscopy of the Macaque Primary Visual Cortex at 7 Tesla: Strategies and Pitfalls of Shimming at the Brain Surface. Magn Reson Imaging 25, 902-912 (2007).
  • Juchem C, Muller-Bierl B, Schick F, Logothetis NK, Pfeuffer J. Combined Passive and Active Shimming for In Vivo MR Spectroscopy at High Magnetic Fields. J Magn Reson 183, 278−289 (2006).