The Vedula group is focused on developing computational tools to advance our understanding of cardiovascular disease and development and assist in designing medical devices and treatment planning. They develop novel computational techniques for patient-specific modeling of cardiovascular function, applying core principles of mechanics and computing, including fluid and solid mechanics, combined with data-driven approaches, multiscale modeling, machine learning, optimization, and uncertainty quantification.
Heart disease continues to be the leading cause of death in the world. About 1 in 3 deaths are attributed to cardiovascular disease. Every year, thousands of babies are born with a heart defect, and about 1 in 4 such births are critical. The Vedula group aims to improve the clinical management of cardiovascular disease using computational modeling. Collaborating with a team of cardiologists and cardiothoracic surgeons at the medical school (CUMC) in both adult and pediatric disciplines, Dr. Vedula’s group identifies unmet clinical needs and engineers solutions using innovative interdisciplinary strategies at the interface of computational mechanics, multiscale modeling, data science, and machine learning.
Vedula received a Ph.D. in Mechanical Engineering from Johns Hopkins University in 2015 and underwent postdoctoral training in the Department of Pediatrics at Stanford University. He is a member of the American Society of Mechanical Engineers, American Physical Society, and American Heart Association.
PROFESSIONAL EXPERIENCE
- Columbia University, Mechanical Engineering, New York, NY Assistant Professor, Jan 2020 - present
- Stanford University, Pediatrics, Stanford, CA Postdoctoral research associate, Jun 2015 - Dec 2019
- UC San Diego, Mechanical and Aerospace Engineering, San Diego, CA Postdoctoral research associate, Feb 2015 - June 2015
- Johns Hopkins University, Mechanical Engineering, Baltimore, MD Graduate research assistant, Aug 2010 - Feb 2015
- GE India Technology Center, Bangalore, India Engineer, Dec 2009 - Aug 2010
- Tridiagonal Solutions Pvt. Ltd., Pune, India CFD Engineer, Aug 2009 - Dec 2009
PROFESSIONAL AFFILIATIONS
- American Society of Mechanical Engineers
- American Physical Society
- American Heart Association
HONORS & AWARDS
- Theodore von Karman Fellowship, RWTH Aachen University, 2018.
- Child Health Research Institute Grant & Postdoctoral Fellowship, Stanford University Medical School, 2016-2017.
- NSF-sponsored Young Investigator & Travel Award, 5th Engineering Frontiers Conference on Pediatrics and Congenital Heart Disease, Orlando, Florida 2016.
- Gordon L. and Beatrice C. Bowles Fellowship, Johns Hopkins University, 2010.
- I.I.T. Kanpur Academic Excellence Award, Indian Institute of Technology Kanpur, 2009.
- General Electric (GE) Foundation Scholar-Leader 2008.
SELECTED PUBLICATIONS
- Vedula, V., George, R., Younes, L. and Mittal, R., 2015. “Hemodynamics in the left atrium and its effect on ventricular flow patterns.” Journal of Biomechanical Engineering, 137(11).
- Vedula, V., Seo, J.H., Lardo, A.C. and Mittal, R., 2016. “Effect of trabeculae and papillary muscles on the hemodynamics of the left ventricle.” Theoretical and Computational Fluid Dynamics, 30(1), pp.3-21.
- Vedula, V., Lee, J., Xu, H., Kuo, C.C.J., Hsiai, T.K. and Marsden, A.L., 2017. “A method to quantify mechanobiological forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling.” PLoS Computational Biology, 13(10), p.e1005828.
- Zhu, C.*, Vedula, V.*, Parker, D., Wilson, N., Shadden, S. and Marsden, A., 2022. “svFSI: A multiphysics package for integrated cardiac modeling.” Journal of Open Source Software, 7(78), p.4118. (*equal contribution)
- Brown, A.L., Salvador, M., Shi, L., Pfaller, M.R., Hu, Z., Harold, K.E., Vedula, V.*, and Marsden, A.*, “A modular framework for implicit 3D-0D coupling in cardiac mechanics.” Computer Methods in Applied Mechanics and Engineering, 421, p.116764. (*co-corresponding author)