Qiao Lin

ASSOCIATE PROFESSOR OF MECHANICAL ENGINEERING

236 S.W. Mudd
Mail Code 4703

Tel(212) 854-1906
Fax(212) 854-3304

Qiao Lin’s research addresses biological and medical applications of microelectromechanical systems (MEMS), with an emphasis on using MEMS and microfluidic technologies to create integrated devices and systems for micro- and nanoscale biological sensing and manipulation. These devices and systems aim to allow sensitive and accurate interrogation of biomolecules and cells in well-controlled micro- and nanoscale environments, thereby enabling, in a manner unattainable with conventional methods, new insights into fundamental biological phenomena as well as innovative capabilities for practical biomedical applications.

Research Interests

Microelectromechanical systems (MEMS), microfluidics and nanofluidics, micro- and nanobiosensing, and biomolecular nanotechnology

Research Areas

Lin’s specific research thrusts involve micro- and nanoscale biosensing, aptameric microfluidics, and microfluidic biomolecular and cellular manipulation. Efforts in micro- and nanobiosensing address glucose sensing, biocalorimetry, and nanobiosensing. In glucose sensing, subcutaneously implantable MEMS sensors are created to measure glucose binding-induced changes in the physical properties of functional polymers for accurate and reliable continuous glucose monitoring in diabetes care. Biocalorimetry focuses on developing MEMS devices to directly measure and characterize thermal activities in biological reactions and interactions with reduced cost, higher efficiency, and reduced material consumption. Nanobiosensing exploits biologically functionalized nanomaterials to enable specific and sensitive biomolecular detection in physiological media. Research in aptameric microfluidics explores the use of aptamers (affinity oligonucleotides) for biosensing and manipulation, and addresses the integrated and rapid discovery of aptamers (from randomized oligonucleotides) as personalized reagents in clinical diagnostics and therapeutics. Finally, efforts in microfluidic biomolecular and cellular manipulation involve the selective isolation and enrichment, nondestructive and flexible recovery, and label-free detection of biomolecules and cells using aptamer-based affinity methods or physically based designs. Microfluidic systems are also developed to facilitate biodosimetry via integrated manipulation and gene expression analysis of ionizing beam-irradiated single cells.

Lin received a BS in engineering mechanics from Tsinghua University in 1985 and a PhD in mechanical engineering from the California Institute of Technology in 1998.

RESEARCH EXPERIENCE

  • Postdoctoral scholar, California Institute of Technology, 1998-2000

PROFESSIONAL EXPERIENCE

  • Associate professor of mechanical engineering (with tenure), Columbia University, 2010-
  • Associate professor of mechanical engineering (without tenure), Columbia University, 2005–2010
  • Assistant professor of mechanical engineering, Carnegie Mellon University, 2000–2005
  • Assistant professor of biomedical engineering (by courtesy), Carnegie Mellon University, 2003–2005

PROFESSIONAL AFFILIATIONS

  • American Society of Mechanical Engineers (ASME)
  • Institute of Electrical and Electronics Engineers (IEEE)

SELECTED PUBLICATIONS

  • Z. Zhang, J. Shang, J. Yan, Q. Wang and Q. Lin, “A MEMS Dielectric Affinity Sensor Using Hydrogel Functionalized Coplanar Electrodes for Continuous Glucose Monitoring,” Microfluidics and Nanofluidics, in press.
  • T. Olsen, J. Zhu, J. Kim, R. Pei, M. Stojanovic, and Q. Lin, “An Integrated Microfluidic SELEX Approach Using Combined Electrokinetic and Hydrodynamic Manipulation,” Journal of Laboratory Automation, 22: 63-72, 2017.
  • J. Kim, T. Olsen, J.P. Hilton, K. Yang, R. Pei, M. Stojanovic and Q. Lin, “Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation," Scientific Reports, 6: 26139, 2016.
  • B. Wang, Y. Jia and Q. Lin, “A Microfabrication-Based Approach to Quantitative Isothermal Titration Calorimetry," Biosensors and Bioelectronics, 78: 438-46, 2016.
  • J. Yang, J. Zhu, R. Pei, J. Oliver, D. Landry, M. Stojanovic and Q. Lin, “An Integrated Microfluidic Aptasensor for Mass Spectrometric Detection of Vasopressin in Human Plasma Ultrafiltrate,” Analytical Methods, 8: 5190-5196, 2016. (Featured Cover Article)
  • Y. Zhu, Y. Hao, E. Adogla, J. Yan, D. Li, K. Xu, Q. Wang, J. Hone and Q. Lin, “A Graphene-Based Affinity Nanosensor for Detection of Low-Charge and Low-Molecular-Weight Molecules,” Nanoscale, 8: 5815-5819, 2016.
  • J. Hilton, T. Olsen, J. Kim, J. Zhu, T. Nguyen, M. Barbu, R. Pei, M. Stojanovic, and Q. Lin, "Isolation of thermally sensitive protein-binding oligonucleotides on a microchip," Microfluidics and Nanofluidics, 19, 795-804, 2015.
  • C. Wang, J. Kim, J. Zhu, J. Yang, R. Pei, G. Liu, J. Hone, M. Stojanovic and Q. Lin, “A Graphene Nanosensor for Detection of Small Molecules," Biosensors and Bioelectronics, 71, 222-229, 2015.
  • X. Huang, J. Oxsher, C. LeDuc, Y. Ravussin, Q. Wang, D. Accili, R. Leibel and Q. Lin, “A Microfabricated Differential Dielectric Affinity Biosensor,” Lab on a Chip, 14: 294-301, 2014. (Featured Cover Article)
  • J. Zhu, T.H. Nguyen, R. Pei, M. Stojanovic and Q. Lin, “Specific Capture and Temperature Mediated Release of Cells Using Aptamer-Functionalized Microfluidic Surfaces,” Lab on a Chip, 12: 3504-13, 2012.