BME Seminar: Steve Adie, Cornell University
Friday,
October 12, 2018
11:00 AM - 12:00 PM
All are welcome, (attendance required for graduate students). Lunch is provided.
Steven G. Adie, Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
Volumetric imaging of biophysical cell-matrix interactions with optical coherence microscopy
Over the last decade, mechanobiology research has highlighted the importance of matrix mechanical properties, as well as dynamic, biophysical cell-matrix interactions. Cell-matrix interactions are also known to be influenced by whether cells are in 3D versus 2D environments, and whether they are isolated or part of a collective/population. Currently available imaging technologies for the study of biophysical cell-matrix interactions do not offer the spatiotemporal coverage for volumetric, time-lapse imaging studies of cell forces in both isolated and collective settings. In this talk I will present our recent work on the development of traction force optical coherence microscopy (TF-OCM), a new approach to expand the spatiotemporal coverage available for the study of cell force dynamics in 3D environments, and photonic force optical coherence elastography (PF-OCE), a new method for 3D mechanical microscopy based on optical ‘pushing’ of beads embedded in viscoelastic hydrogels. Examples in tissue phantoms and engineered cell cultures will be shown to demonstrate the potential of these methods for cell mechanics research.
Volumetric imaging of biophysical cell-matrix interactions with optical coherence microscopy
Over the last decade, mechanobiology research has highlighted the importance of matrix mechanical properties, as well as dynamic, biophysical cell-matrix interactions. Cell-matrix interactions are also known to be influenced by whether cells are in 3D versus 2D environments, and whether they are isolated or part of a collective/population. Currently available imaging technologies for the study of biophysical cell-matrix interactions do not offer the spatiotemporal coverage for volumetric, time-lapse imaging studies of cell forces in both isolated and collective settings. In this talk I will present our recent work on the development of traction force optical coherence microscopy (TF-OCM), a new approach to expand the spatiotemporal coverage available for the study of cell force dynamics in 3D environments, and photonic force optical coherence elastography (PF-OCE), a new method for 3D mechanical microscopy based on optical ‘pushing’ of beads embedded in viscoelastic hydrogels. Examples in tissue phantoms and engineered cell cultures will be shown to demonstrate the potential of these methods for cell mechanics research.
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