BME Seminar: Lihong Wang, California Institute of Technology
Friday,
November 16, 2018
11:00 AM - 12:00 PM
Facebook
TwitterAll are welcome, (attendance required for graduate students). Lunch is provided.
Lihong V. Wang, Bren Professor, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology
World’s Deepest-Penetration and Fastest Optical Cameras:
Photoacoustic Tomography and Compressed Ultrafast Photography
We developed photoacoustic tomography to peer deep into biological tissue. Photoacoustic
tomography (PAT) provides in vivo omniscale functional, metabolic, molecular, and histologic
imaging across the scales of organelles through organisms. We also developed compressed
ultrafast photography (CUP) to record 10 trillion frames per second, 10 orders of magnitude
faster than commercially available camera technologies. CUP can tape the fastest phenomenon in the universe, namely, light propagation, and can be slowed down for slower phenomena such as combustion.
PAT physically combines optical and ultrasonic waves. Conventional high-resolution
optical imaging of scattering tissue is restricted to depths within the optical diffusion limit (~1
mm in the skin). Taking advantage of the fact that ultrasonic scattering is orders of magnitude
weaker than optical scattering per unit path length, PAT beats this limit and provides deep
penetration at high ultrasonic resolution and high optical contrast by sensing molecules. Broadapplications include early-cancer detection and brain imaging. The annual conference on PAT has become the largest in SPIE’s 20,000-attendee Photonics West since 2010.
CUP can image in 2D non-repetitive time-evolving events. CUP has a prominent
advantage of measuring an x, y, t (x, y, spatial coordinates; t, time) scene with a single exposure, thereby allowing observation of transient events occurring on a time scale down to 100 femtoseconds. Further, akin to traditional photography, CUP is receive-only—avoiding
specialized active illumination required by other single-shot ultrafast imagers. CUP can be
coupled with front optics ranging from microscopes to telescopes for widespread applications in both fundamental and applied sciences.
World’s Deepest-Penetration and Fastest Optical Cameras:
Photoacoustic Tomography and Compressed Ultrafast Photography
We developed photoacoustic tomography to peer deep into biological tissue. Photoacoustic
tomography (PAT) provides in vivo omniscale functional, metabolic, molecular, and histologic
imaging across the scales of organelles through organisms. We also developed compressed
ultrafast photography (CUP) to record 10 trillion frames per second, 10 orders of magnitude
faster than commercially available camera technologies. CUP can tape the fastest phenomenon in the universe, namely, light propagation, and can be slowed down for slower phenomena such as combustion.
PAT physically combines optical and ultrasonic waves. Conventional high-resolution
optical imaging of scattering tissue is restricted to depths within the optical diffusion limit (~1
mm in the skin). Taking advantage of the fact that ultrasonic scattering is orders of magnitude
weaker than optical scattering per unit path length, PAT beats this limit and provides deep
penetration at high ultrasonic resolution and high optical contrast by sensing molecules. Broadapplications include early-cancer detection and brain imaging. The annual conference on PAT has become the largest in SPIE’s 20,000-attendee Photonics West since 2010.
CUP can image in 2D non-repetitive time-evolving events. CUP has a prominent
advantage of measuring an x, y, t (x, y, spatial coordinates; t, time) scene with a single exposure, thereby allowing observation of transient events occurring on a time scale down to 100 femtoseconds. Further, akin to traditional photography, CUP is receive-only—avoiding
specialized active illumination required by other single-shot ultrafast imagers. CUP can be
coupled with front optics ranging from microscopes to telescopes for widespread applications in both fundamental and applied sciences.
LOCATION:
← BACK TO EVENTS
- Morningside
- Seminar
- Engineering
- Alumni
- Faculty
- Graduate Students
- Prospective Students
- Postdocs
- Public
- Staff
- Students
- Trainees
Date Navigation Widget
Export Options
Getting to Columbia
Other Calendars
- Alumni Events
- Barnard College
- Columbia Business School
- Columbia College
- Committee on Global Thought
- Heyman Center
- Jewish Theological Seminary
- Miller Theatre
- School of Engineering & Applied Science
- School of Social Work
- Teachers College
Guests With Disabilities
- Columbia University makes every effort to accommodate individuals with disabilities. Please notify us if you need any assistance by contacting the event’s point person. Alternatively, the Office of Disability Services can be reached at 212.854.2388 and [email protected]. Thank you.