BME BREAKS: Tal Danino, PhD, Columbia University
Friday,
June 26, 2020
12:00 PM - 1:00 PM
Online Event
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TwitterOn Friday, June 26th @ 12:00PM EDT, we welcome Dr. Tal Danino from the Department of Biomedical Engineering at Columbia University as he presents, "Engineering bacteria for cancer therapy."
ABOUT THE JUNE 26 WEBINAR
Over the past decade, microbiome research has revealed an astounding prevalence of bacteria in both healthy and diseased tissue. This natural presence of bacteria has renewed interest in programming microbes to sense and respond to disease states using approaches from synthetic biology. One particular focus is cancer therapy, where a multitude of studies have demonstrated selective colonization of solid tumors by bacteria, primarily due to reduced immune surveillance in tumor cores. In this talk, I will describe our laboratory's progress in building a multi-scale framework for engineering bacteria as a diagnostic and therapeutic agent for cancer. We use a methodology that bridges in silico computational modeling, in vitro characterization and platform development, and in vivo mouse models for cancer. We will highlight recent examples of bacteria programmed to sense and respond to tumor environments and release specific therapeutic payloads ranging from cytotoxic to immunomodulatory agents. This approach allows for the creation of engineered systems that intelligently sense and respond to diverse environments, ultimately adding specificity and efficacy that extends beyond the capabilities of molecular-based therapeutics.
ABOUT THE SPEAKER
Tal Danino, Ph.D.
Assistant Professor of Biomedical Engineering
Columbia University
Tal Danino is an Assistant Professor in the Department of Biomedical Engineering at Columbia University. His lab focuses on engineering bacteria for biomedical applications, with a particular emphasis on developing bacteria as a cancer therapy. Originally from Los Angeles, Tal received a Ph.D. in Bioengineering from UCSD in Jeff Hasty's lab, and was a postdoctoral fellow at the Koch Institute for Integrative Cancer Research with Sangeeta Bhatia. He is the recipient of awards including the NSF CAREER Award, Era of Hope Scholar Award, TED Fellow, and NIH Pathway to Independence Award. He directs the Synthetic Biological Systems Laboratory and is a member of the Herbert Irving Comprehensive Cancer Center and Data Science Institute.
BME BREAKS SCHEDULE
July 10 - Simone Schürle-Finke, PhD, ETH Zürich
“Engineering micro- and nanorobots for medicine”
July 17 - Gordana Vunjak-Novakovic, PhD, Columbia University BME
“Engineering human tissues for medical impact”
July 24 - Rong Gan, PhD, University of Oklahoma
“Measurement and modeling of blast-induced auditory injury in animal model of chinchilla”
July 31 - Elham Azizi, PhD, Columbia University BME
“Machine learning for modeling the dynamics of the tumor microenvironment”
August 7 - James J. Collins, PhD, MIT
“Synthetic biology: life redesigned”
August 14 - José McFaline-Figueroa, PhD, University of Washington
“Defining drug-induced molecular landscapes with multiplex single-cell genomics”
August 21 - Christoph Juchem, PhD, Columbia University BME
“Magnetic resonance engineering - from bench to bedside”
ABOUT THE JUNE 26 WEBINAR
Over the past decade, microbiome research has revealed an astounding prevalence of bacteria in both healthy and diseased tissue. This natural presence of bacteria has renewed interest in programming microbes to sense and respond to disease states using approaches from synthetic biology. One particular focus is cancer therapy, where a multitude of studies have demonstrated selective colonization of solid tumors by bacteria, primarily due to reduced immune surveillance in tumor cores. In this talk, I will describe our laboratory's progress in building a multi-scale framework for engineering bacteria as a diagnostic and therapeutic agent for cancer. We use a methodology that bridges in silico computational modeling, in vitro characterization and platform development, and in vivo mouse models for cancer. We will highlight recent examples of bacteria programmed to sense and respond to tumor environments and release specific therapeutic payloads ranging from cytotoxic to immunomodulatory agents. This approach allows for the creation of engineered systems that intelligently sense and respond to diverse environments, ultimately adding specificity and efficacy that extends beyond the capabilities of molecular-based therapeutics.
ABOUT THE SPEAKER
Tal Danino, Ph.D.
Assistant Professor of Biomedical Engineering
Columbia University
Tal Danino is an Assistant Professor in the Department of Biomedical Engineering at Columbia University. His lab focuses on engineering bacteria for biomedical applications, with a particular emphasis on developing bacteria as a cancer therapy. Originally from Los Angeles, Tal received a Ph.D. in Bioengineering from UCSD in Jeff Hasty's lab, and was a postdoctoral fellow at the Koch Institute for Integrative Cancer Research with Sangeeta Bhatia. He is the recipient of awards including the NSF CAREER Award, Era of Hope Scholar Award, TED Fellow, and NIH Pathway to Independence Award. He directs the Synthetic Biological Systems Laboratory and is a member of the Herbert Irving Comprehensive Cancer Center and Data Science Institute.
BME BREAKS SCHEDULE
July 10 - Simone Schürle-Finke, PhD, ETH Zürich
“Engineering micro- and nanorobots for medicine”
July 17 - Gordana Vunjak-Novakovic, PhD, Columbia University BME
“Engineering human tissues for medical impact”
July 24 - Rong Gan, PhD, University of Oklahoma
“Measurement and modeling of blast-induced auditory injury in animal model of chinchilla”
July 31 - Elham Azizi, PhD, Columbia University BME
“Machine learning for modeling the dynamics of the tumor microenvironment”
August 7 - James J. Collins, PhD, MIT
“Synthetic biology: life redesigned”
August 14 - José McFaline-Figueroa, PhD, University of Washington
“Defining drug-induced molecular landscapes with multiplex single-cell genomics”
August 21 - Christoph Juchem, PhD, Columbia University BME
“Magnetic resonance engineering - from bench to bedside”
RSVP at the link above!
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